Understanding Molecular Classifications of Gynecologic Cancers

Endometrial Cancer

Similar to ovarian cancer, there can be genetic causes at the root of an endometrial cancer diagnosis. It is most commonly a condition called Lynch syndrome, which, according to the Centers for Disease Control and Prevention(USA), is a hereditary condition that predisposes people to colon, endometrial and other cancers.

Lynch syndrome-related cancer may have DNA mismatch repair deficiency (dMMR) and microsatellite instability (MSI or MSI-H). dMMR occurs when DNA strands cannot be properly replicated, leading to mutations. These mutations result in MSI-H cancers.

https://www.curetoday.com/view/understanding-molecular-classifications-of-gynecologic-cancers

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