The Manchester International Consensus Group

Provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

“Our key recommendations are as follows: The Manchester International Consensus Group recommendations for the management of gynecologicalcancers in Lynch syndrome:

(1) all stakeholders should be informed of the impact of Lynch syndrome on gynecological cancer risk;

(2) systems should be established to screen for Lynch syndrome in women with endometrial cancer;

(3) women at risk of Lynch syndrome should be offered risk-reducing hysterectomy with bilateral salpingo-oophorectomy, at a time appropriate to them; and

(4) further research is required to establish the value ofgynecological cancer surveillance in Lynch syndrome and toexplore other key areas where there is currently deficientevidence to define appropriate standards of care.

Screening for Lynch syndrome is only recommended if effective management exists to benefit those who screen positive.The strength of our guidance comes from the broad andexpert medical specialty representation that forms ourConsensus Group.”

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