Among the people who tested positive for non-founder #BRCA mutations, 89.7% [had] false-positive results. A false-positive result means the #genetic test shows you have a genetic mutation when you really don’t.
CONCLUSION
Direct to Consumer genetic testing misses >90% of BRCA1/2 pathogenic/likely pathogenic variants in individuals of non-AJ(non-Jewish) ancestry and about 10% of BRCA1/2 PLPV among AJ individuals. There is a high false-positivity rate for non-AJ BRCA 1/2 PLPV with DTC genetic testing.
Lynch Syndrome Ireland 