Understanding the complex interplay between host factors such as gPVs (Germline Pathogenic Variant), gut microbiome, and extrinsic environmental factors will be critical to mitigate the rising incidence of EO cancer globally, particularly across the spectrum of GI cancers.
Practical Applications
Awareness of the early-onset (EO) cancer epidemic should prompt heightened vigilance among health care providers caring for patients who would not be historically considered at high risk for cancer.
Early detection of symptoms with appropriate diagnostic testing is critical to obtaining a cancer diagnosis in earlier stages which may allow for a greater chance of curative approaches.
Multidisciplinary management of patients with EO cancers is critical to address unique and challenging issues that younger populations must navigate, including family, social, career, and financial stress.
Genetic counselling and testing are critical components to multidisciplinary care and may elucidate mechanisms of EO cancer development.
Lynch Syndrome Ireland 