Total neoadjuvant therapy for rectal cancer: a guide for surgeons

(Neoadjuvant: First step to shrink a tumour before the main treatment)

The modern management of rectal cancers continues to evolve.

With the release of data from new landmark randomized controlled trials (RAPIDO, PRODIGE-23), total neoadjuvant therapy (TNT) has moved to the forefront of locally advanced rectal cancer treatment and is considered a standard option in selected patients.

Surgeons have a fundamental role in the treatment of patients with rectal cancer. Although neoadjuvant or adjuvant treatments certainly can improve outcomes, definitive curative-intent treatment still depends on complete surgical resection as standard therapy.

https://www.canjsurg.ca/content/66/2/E196

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