Key content
- Lynch syndrome is an autosomal dominant condition closely associated with colorectal, endometrial and ovarian cancer.
- Women with Lynch syndrome are at increased risk of both endometrial and ovarian cancer and should be offered personalised counselling regarding family planning, red flag symptoms and risk-reducing strategies.
- Surveillance for gynaecological cancer in women with Lynch syndrome remains controversial; more robust data are needed to determine its effectiveness.
- Universal testing for Lynch syndrome in endometrial cancer is being adopted by centres across Europe and is now recommended by the National Institute for Health and Care Excellence; thus, gynaecologists must become familiar with testing strategies and their results.
- Testing strategies involve risk stratification of cancers based on phenotypical features and definitive germline testing.
https://obgyn.onlinelibrary.wiley.com/doi/10.1111/tog.12706
Lynch Syndrome Ireland 