“People with Lynch Syndrome can benefit from screening programmes that enable cancers to be found at an early stage when they can be cured “
Patients with LS are at high risk of bowel and endometrial cancers. The risk of urothelial cancer is less well recognised, with a lifetime risk of up to 28.5%, depending on which gene is involved.
This means that those LS patients who have an underlying defect in the MSH2 gene are more than 10 times as likely to get a potentially curable cancer in their urinary tract than the general population.
Failure to screen for these cancers means that even after being diagnosed with the condition, one in 20 LS patients will die of urothelial cancer, often at a young age.
https://www.ncl.ac.uk/press/articles/latest/2021/11/lynchsyndrome/
Lynch Syndrome Ireland 