Report a focused somatic mutation and frameshift-neoAg landscape of microsatellite loci from colorectal polyps without malignant potential (PWOMPs), precancers, and early-stage cancers in LS carriers.
Conclusions
Shared frameshift-neoAgs are generated within unstable microsatellite loci at initial stages of LS carcinogenesis and can induce T-cell responses, generating opportunities for vaccine development, targeting LS precancers and early-stage cancers.
https://www.sciencedirect.com/science/article/pii/S0016508524000520
Lynch Syndrome Ireland 