The International Society for Gastrointestinal Hereditary Tumours (InSiGHT) is a multidisciplinary scientific organisation, whose mission is to improve the care of patients and families worldwide with any hereditary condition resulting in gastrointestinal tumours.
They have nearly 300 members, including scientists, clinicians and other healthcare professionals, from all parts of the world.
Lynch Syndrome Risks
The Prospective Lynch Syndrome Database (PLSD) now provides the most accurate estimates of cancer risks in LS, both in individuals who have yet to develop a cancer and those who have survived a cancer. An individual’s risks can be found according to their age, gender and the underlying gene.
Lynch syndrome-related tumours include:
- Colon and rectal cancer
- Endometrial cancer
- Small intestine cancer (MSH2 & MLH1)
- Hepato-biliary and pancreatic cancer (MSH2 & MLH1)
- Gastric cancer (MSH2 & MLH1)
- Ovarian non-serous cancer (MSH2 & MLH1)
- Renal pelvis and ureter cancer (MSH2 & MSH6)
- Bladder cancer(MSH2 & MSH6)
- Sebaceous gland cancer (and adenoma – Muir-Torre syndrome)
- Prostate cancer (MSH2)
- Breast cancer (MLH1)
- Central nervous system cancer
The risks associated with some EPCAM deletions appear not to be restricted to GI cancers.
Lynch Syndrome Ireland 