FIT for Lynch Study – New diagnostic techniques for bowel cancer detection and prevention

The St Mark’s Lynch Syndrome Clinic is undertaking a range of projects which are being supported by 40tude Curing Colon Cancer. One of the projects aims to develop more tests which facilitate the prevention and early diagnosis of cancer in people with Lynch Syndrome (LS).

Dr Kevin Monahan, a consultant gastroenterologist at St Mark’s, says, ‘‘We’re working closely with people with LS to design national health services – our work can’t be achieved without them. The FIT for Lynch Study is the first longitudinal study of its kind which will assess the potential role of faecal immunochemical testing (FIT) as a means of bowel cancer surveillance in people with LS. 

Is colon cancer hereditary?

All cancers are genetic because changes in genes cause cells to grow out of control, leading to the disease. However, genetic does not mean hereditary

Hereditary cancers are cancers that pass from generation to generation via genes. These cancers comprise only a small portion of colon cancers.

Lynch syndrome causes about 5% of all colorectal cancers.

Biomarkers in Colon Cancer: What Does High Microsatellite Instability Mean?

Tumours that are MSI high have a lot of mutations on their surface. A lot of mutations are needed for the immune system to recognise the cancer.
For the majority of solid tumours, the immune system doesn’t really care that you have cancer.
But in tumours that are MSI-High, they have a lot of proteins on their surface that are kind of like signs for the immune system to say ‘Hey, I’m here! Come fight me!’ And then the immune system sees those mutations, kicks in, and sends T cells.

If the tumour is dMMR/MSI-H, additional tests are required to determine if the MSI-H is caused by Lynch syndrome….”

“Having been through cancer and the shock of discovering he has Lynch syndrome, Andrew is well today but knows it is important to continue to be vigilant with both physical and mental health”

https://www.irishtimes.com/life-and-style/health-family/my-surgeon-got-straight-to-the-point-you-have-stage-three-colon-cancer-1.3849573#.X5KdBWPkCKQ.mailto

AGA Guideline on the Diagnosis and Managment of Lynch Syndrome

AGA Guidelines: A helpful tool for your GI doctor

According to the American Gastroenterological Association (AGA), all colorectal cancer patients should undergo tumor testing to see if they carry Lynch syndrome, the most common inherited cause of colorectal cancer, according to a new AGA guideline. They have provided an excellent resource for GI doctors on how to go about testing individuals with colorectal cancer for Lynch syndrome, as well as how to manage their screening if they do have Lynch syndrome. If you have recently been diagnosed with colon cancer or have a diagnosis of Lynch syndrome please print this PDF and take it to your GI doctor or GI Oncologist to be sure you are getting the right testing and management for colon cancer associated with Lynch syndrome.

AGA Guideline on the Diagnosis and Managment of Lynch Syndrome

http://www.gastro.org/info_for_patients/2015/8/11/a-patient-guide-understanding-lynch-syndrome

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