Among patients with mismatch repair–deficient (dMMR), locally advanced rectal cancer, neoadjuvant checkpoint blockade eliminated the need for surgery in a high proportion of patients. Whether this approach can be extended to all early-stage dMMR solid tumours, regardless of tumour site, is unknown.
A total of 117 patients were included in the analysis. Phase 2 study.
CONCLUSIONS
Among patients with early-stage dMMR solid tumours that were amenable to curative-intent surgery, neoadjuvant PD-1 blockade led to organ preservation in a high proportion of patients.
https://www.nejm.org/doi/full/10.1056/NEJMoa2404512?query=WB
Lynch Syndrome Ireland 