Background & Aims
Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. The choice of extended or partial colectomy in patients with LS with primary CRC may influence the risk of metachronous CRC. This study aimed to identify factors associated with metachronous CRC risk and evaluate their potential implications for surgical decision-making.
Metachronous (CRC) is a new, separate primary cancer of the colorectum that develops after a patient has already been diagnosed with and treated for an initial CRC.
Conclusions:
This study identifies important risk factors for metachronous CRC in patients with LS, which may support personalised counseling regarding surgical strategies. The findings highlight the complexity of surgical decision-making and the need for individualised approaches. Further studies are required to refine risk stratification and evaluate long-term outcomes to optimise patient care.
https://www.cghjournal.org/article/S1542-3565(25)00638-X/fulltext
Lynch Syndrome Ireland 