Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report


Premenopausal oophorectomies in patients not at increased risk of ovarian cancer.•

Uptake of risk-reducing surgery (RRS) in Lynch syndrome aligns poorly with cancer risk and mortality.•

Uptake of RRS does not correspond well with current clinical guidelines.•

There is an unmet need for multidisciplinary planning to avoid repeated surgery.


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