When you agree to genetic testing, you expect a yes or no answer: yes, you have an abnormal change in a gene that increases your cancer risk, or no, you don’t. But sometimes, you might not get a clear “yes” or “no.” You might just get a “maybe.”
Are genetic variants of uncertain significance common?
Almost 20% of genetic tests identify a VUS. These tests come in different “sizes.” Some examine only a handful of genes associated with cancer at a time, while others analyze up to 80 genes. The more genes you look at, the more variants of uncertain significance you’ll find.
https://www.mdanderson.org/prevention-screening/family-history/genetic-testing.html
Lynch Syndrome Ireland 