๐๐๐ป๐ฐ๐ต ๐ฆ๐๐ป๐ฑ๐ฟ๐ผ๐บ๐ฒ
A new review in the Journal of Medical Genetics examines an important question: ๐๐ผ๐ ๐ฒ๐ณ๐ณ๐ฒ๐ฐ๐๐ถ๐๐ฒ ๐ถ๐ ๐ฟ๐ฒ๐ด๐๐น๐ฎ๐ฟ ๐ฐ๐ผ๐น๐ผ๐ป๐ผ๐๐ฐ๐ผ๐ฝ๐ ๐ฎ๐ ๐ฝ๐ฟ๐ฒ๐๐ฒ๐ป๐๐ถ๐ป๐ด ๐ฐ๐ผ๐น๐ผ๐ฟ๐ฒ๐ฐ๐๐ฎ๐น ๐ฐ๐ฎ๐ป๐ฐ๐ฒ๐ฟ ๐ถ๐ป ๐๐๐ป๐ฐ๐ต ๐๐๐ป๐ฑ๐ฟ๐ผ๐บ๐ฒ?
The answer is more complicated than we once thought.
๐ช๐ต๐ฎ๐ ๐ฑ๐ผ๐ฒ๐ ๐๐ต๐ฒ ๐ฒ๐๐ถ๐ฑ๐ฒ๐ป๐ฐ๐ฒ ๐๐ต๐ผ๐?
Regular colonoscopy has a ๐ฐ๐น๐ฒ๐ฎ๐ฟ ๐ฏ๐ฒ๐ป๐ฒ๐ณ๐ถ๐ ๐ถ๐ป ๐ฟ๐ฒ๐ฑ๐๐ฐ๐ถ๐ป๐ด ๐ฐ๐ผ๐น๐ผ๐ฟ๐ฒ๐ฐ๐๐ฎ๐น ๐ฐ๐ฎ๐ป๐ฐ๐ฒ๐ฟ ๐ฑ๐ฒ๐ฎ๐๐ต๐. However, it may not completely prevent colorectal cancer from developing.
Lynch syndrome cancers can sometimes develop through an ๐ฎ๐ฐ๐ฐ๐ฒ๐น๐ฒ๐ฟ๐ฎ๐๐ฒ๐ฑ ๐ฝ๐ฎ๐๐ต๐๐ฎ๐ that bypasses the typical polyp โ cancer sequence. Some cancers may develop without a conventional, easily detectable precursor polyp.
That means someone can follow recommended surveillance and still develop colorectal cancer.
๐ง๐ต๐ถ๐ ๐๐ข๐๐ฆ ๐ก๐ข๐ง ๐บ๐ฒ๐ฎ๐ป ๐ฐ๐ผ๐น๐ผ๐ป๐ผ๐๐ฐ๐ผ๐ฝ๐ ๐ถ๐๐ป’๐ ๐๐ผ๐ฟ๐ธ๐ถ๐ป๐ด.
Surveillance can help detect cancers ๐ฒ๐ฎ๐ฟ๐น๐ถ๐ฒ๐ฟ, when they are more treatable, helping reduce colorectal cancer mortality.
The review highlights ways to improve surveillance, including:
๐น High-quality colonoscopy
๐น Gene-specific surveillance intervals
๐น Chromoendoscopy & AI-assisted detection
๐น FIT testing between colonoscopies
๐น Aspirin chemoprevention
๐น Biomarker-guided strategies
๐น Continued research
And remember: ๐๐๐ป๐ฐ๐ต ๐๐๐ป๐ฑ๐ฟ๐ผ๐บ๐ฒ ๐ถ๐ ๐ป๐ผ๐ ๐๐ต๐ฒ ๐๐ฎ๐บ๐ฒ ๐ณ๐ผ๐ฟ ๐ฒ๐๐ฒ๐ฟ๐๐ผ๐ป๐ฒ. Cancer risks can differ between ๐๐๐1, ๐๐๐2, ๐๐๐6, and ๐๐๐2 carriers.
๐ง๐๐ ๐ง๐๐๐๐๐ช๐๐ฌ:
Keep your recommended surveillance appointments. Colonoscopy remains an essential tool for Lynch syndrome, and the evidence strongly supports its ability to ๐ฟ๐ฒ๐ฑ๐๐ฐ๐ฒ ๐ฐ๐ผ๐น๐ผ๐ฟ๐ฒ๐ฐ๐๐ฎ๐น ๐ฐ๐ฎ๐ป๐ฐ๐ฒ๐ฟ ๐ฑ๐ฒ๐ฎ๐๐ต๐.
๐ ๐ฅ๐ฒ๐ฎ๐ฑ ๐๐ต๐ฒ ๐ณ๐๐น๐น ๐ฟ๐ฒ๐๐ถ๐ฒ๐:
https://jmg.bmj.com/content/63/6/337.abstract
Lynch Syndrome Ireland 