In Lynch syndrome, colorectal cancer receives the most attention — but gynaecological risk requires equal clinical vigilance.
For women with Lynch syndrome, the lifetime risk of endometrial cancer is substantially elevated and varies according to the gene affected, reaching up to 40–60% in carriers of pathogenic MLH1 and MSH2 variants. Endometrial cancer is frequently the first, or ‘sentinel’, cancer diagnosed.
Awareness of early symptoms — including abnormal or postmenopausal bleeding — together with adherence to established surveillance guidelines, supports earlier diagnosis. PREDI-LYNCH incorporates gynaecological clinical data so that predictive models reflect risk in women accurately.
Lynch Syndrome Ireland 