http://gyncsm.blogspot.com/2024/03/march-13-2024-using-immunotherapies-to.html
Author: Lynch Syndrome Ireland
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
MMR: Cells that have mutations (changes) in certain genes that are involved in correcting mistakes made when DNA is copied in a cell. Mismatch repair (MMR) deficient cells usually have many DNA mutations, which may lead to cancer.
This paper from the @PLSDatabase describes the cumulative lifetime incidences compared to estimated general population incidences
Conclusion: Carriers of different path_MMR variants exhibit distinct patterns of cancer risk and survival as they age. Risk estimates for counselling and planning of surveillance and treatment should be tailored to each patient’s age, gender and path_MMR variant.
Does Lynch syndrome itself have any symptoms?
Genomic Data Infrastructure (GDI) Ireland
Genomic Data Infrastructure (GDI) Ireland is the Irish arm of the European GDI project which aims to create federated genetic data infrastructures across Europe to allow for safe and secure sharing of genomic data.
15 Common Types of Fear People With Chronic Illness Experience (and How to Cope)
New Approaches to Management: Immunotherapy to Treat Lynch Syndrome Cancers
Lynch Syndrome: More Than One Syndrome: Gene Specific Risks
Support Early Detection, Enhance Quality of Life
A book that sheds light on the alarming spread of early-onset colorectal cancer (eo-CRC) among individuals under the age of 50. At Digestive Cancers Europe (DiCE), our commitment to spreading information about eo-CRC and its prevention has driven us to work intensively on this topic for the past few years.
The Free book’s last chapter reflects on life before and after the disease. The young protagonists, hailing from nine different European countries, lead diverse lives but show us the power of courage and resilience. They exemplify how the support of loved ones is crucial in facing colorectal cancer with determination.
Irish cancer survivors need
Cancer survivors should have legal protection to ensure they are not discriminated against when it comes to financial products such as life insurance, an international conference has heard.
Last December, Insurance Ireland said a new voluntary code of practice would see insurers disregard a cancer diagnosis where treatment ended more than seven years before an application for products such as life, mortgage protection or income protection policies.
Where an applicant was under 18 at the time their cancer treatment stopped, the right to be forgotten will apply after five years.
Cover of up to €500,000 per applicant is to be allowed under the revised code, a ceiling that Insurance Ireland says covers more than 90pc of mortgage protection policies issued in the State.
However, it is still not underpinned by legislation. A spokesperson for the Department of Finance said the right to be forgotten aims to ensure equal access to financial services for individuals who have recovered from a previous illness.
Giving immune system cancer-attacking power back
For a cancerous tumor to grow, it must overpower immune cells known as T cells. TIL((tumor-infiltrating lymphocyte – or TIL therapy) is showing promise in advanced lung cancers through clinical trials underway. Therapy restores the immune system’s natural ability to fight cancer cells.
Lynch Syndrome Ireland 