Author: Lynch Syndrome Ireland

PSA Screening for Aggressive Prostate Cancer Supported in Men With Lynch Syndrome

Men carrying MSH2 and MSH6 pathogenic variants, which are associated with Lynch syndrome, were found to have a higher incidence of prostate cancer compared with age-matched non-carrier individuals, supporting the value of annual, targeted prostate-specific antigen (PSA) screening from age 40 to identify men with clinically significant prostate cancer, according to the initial results of the IMPACT study (NCT00261456) that were published in The Lancet Oncology.1

https://www.onclive.com/view/psa-screening-for-aggressive-prostate-cancer-supported-in-men-with-lynch-syndrome-associated-pathogenic-variants

Keeping Patients Up to Date After Genetic Testing

Click to access My-Gene-Counsel-White-Paper-Keeping-Patients-Up-to-Date-After-Genetic-Testing.pdf

“A patient can have the most thorough and accurate genetic testing available, but if that information is not integrated into their health care, that testing is meaningless. Or worse, if that testing is not interpreted correctly, it can be harmful”

Should children be Tested for Hereditary Syndromes?

“It is generally not a good idea to genetically test minor children for hereditary cancer syndromes, such as Lynch syndrome or BRCA, unless their family medical history warrants it.”

https://www.curetoday.com/view/should-children-be-tested-for-hereditary-cancer-syndromes-?fbclid=IwAR12H4WIHzF5Y-FbmD-9wOOSfzoTKMqZSFO6NQtfxlYLPnuXLJ-Z-CTnBYw

Familial Burden and Other Clinical Factors Associated With Various Types of Cancer in Individuals With Lynch Syndrome

Conclusions: Familial burden – in addition to age, sex, and specific LS gene – should be used to assess LS carriers’ risks of specific cancers and guide decision-making about organ-specific surveillance.

https://pubmed.ncbi.nlm.nih.gov/33794268/

Conquering cancer by targeting its genetic abnormalities

“Some say, ‘Oh, I don’t want to know.’ And I think, well, you’re nuts because knowledge is power, and you can stay ahead of this,” 

https://individualizedmedicineblog.mayoclinic.org/2020/11/11/conquering-cancer-by-targeting-its-genetic-abnormalities/?linkId=121710641

A day in the Life of Bren….

Bren has Lynch Syndrome and is constantly trying to create awareness.

Before and after his scan…..

@bren_below7

#irish #CancerPatient #lynchsyndrome #immunotherapy #resultsday #bren_below7

♬ original sound – Breandán Ó Maoldúin
@bren_below7

Tears of joy #irish #CancerPatient #lynchsyndrome #immunotherapy #resultsday #bren_below7

♬ original sound – Breandán Ó Maoldúin

Colorectal Cancer Screening

Dr @AliceLeBonniec from @nuigalway and Dr Nick Clarke from @DCU are looking to recruit patient and public involvement contributors to help design two @IrishCancerSoc research studies to improve colorectal cancer screening uptake. More details above!