Objective: Estimates of cancer risk and the effects of surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. They have sought to establish more robust estimates in patients undergoing prospective cancer surveillance.
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Managing menopausal symptoms after cancer can be challenging, and more severe than at natural menopause. Menopausal symptoms can extend beyond hot flushes and night sweats (vasomotor symptoms). Treatment-induced symptoms might include sexual dysfunction and impairment of sleep, mood, and quality of life.
Menopausal hormone therapy is an effective treatment for vasomotor symptoms and seems to be safe for many patients with cancer.
When hormone therapy is contraindicated or avoided, emerging evidence supports the efficacy of non-pharmacological and non-hormonal treatments, although most evidence is based on women older than 50 years with breast cancer.
https://www.sciencedirect.com/science/article/pii/S0140673623028027?dgcid=coauthor#fig2
Lynch syndrome may affect up to 175,000 people in the UK and is linked to 3% of cases of womb cancer.
To develop Lynch syndrome you need to have one parent that carries the gene. Someone diagnosed with Lynch syndrome has up to 60% chance of developing womb cancer in their lifetime.
Lynch syndrome is also associated with an increased risk of bowel cancer.
Those diagnosed with Lynch syndrome undergo regular tests to check for bowel cancer and womb cancer, many will be offered a hysterectomy (operation to remove the womb) to prevent womb cancer once they feel their family is complete.
Lynch syndrome is often diagnosed when a strong family history of bowel or womb cancer is noted. If you feel this may apply to you, please speak to your doctor about being referred to a genetics service.
As the landscape of gynaecologic cancer treatment shifts towards treatment based on molecular classification of tumours, knowledge of targeted therapies well-suited for mismatch repair deficient Lynch tumours will be crucial.
Identifying barriers and improving access to risk reduction measures is another future direction in the study of Lynch syndrome, and perhaps the greatest frontier is determining whether Lynch-associated endometrial and ovarian tumors should be treated differently than sporadic endometrial and ovarian tumors.
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1127683/full
The Macmillan Genomics Toolkit is designed to guide healthcare professionals to multiple education resources, pathway guidelines, clinical documents, patient support information and case studies to demonstrate the ‘Gold Standard’ of care once genomics has been embedded into practice. It has been developed in collaboration with expert healthcare professionals and the NHS England National Genomics Education team.
Check out www.thisisGo.ie
An online personalised resource for you and yours who have been impacted by a gynaecological cancer.
Menopause is a unique experience for every women.
Getting the correct information is key. http://thisisGO.ie gives you relevant, up to date and factual information on all aspects. Reflecting national @MenoAfterCancer and international studies. Check us out!
“Please help us to make sure families with Lynch are invited to complete a short digital patient survey to tell us what they think, before we roll this out into clinical practice:
https://southampton.qualtrics.com/jfe/form/SV_1FvPJJEZPVX62aO
If you have an X/Twitter account, please see this post and share it if you can:https://x.com/kohut_kelly/status/1765675956159623324?s=20
A personalised online resource for women impacted by cervical cancer. If you have a partner in your life, this platform can also support them. If you are a health care provider working in the area this can also support you and your
practice.
If you are newly diagnosed, receiving treatment, in surveillance
or living well with and beyond cancer this has information that is
tailored to meet your needs.
Also information on Ovarian, Uterine, Vulval and Vaginal cancers.
In addition a genetic pathway for those impacted by BRCA and Lynch Syndrome.
Lynch Syndrome Ireland 