Endometrial cancer risks, periods, pregnancy, HRT and menopause.
Category: Hysterectomy
Supporting patient pathway though gynaecological cancer
Women themselves may be unaware of the sometimes symptoms or may be too embarrassed to consult a doctor, and there remains a stigma associated with these diagnoses in some quarters. This reticence needs to be overcome and a more positive message developed to improve the prevention, screening, treatment and care of gynaecological cancers so that women throughout Europe have the best chance of survival and quality of life.
Ovarian, uterine, cervix and other gynaecological cancers are among the most common cancers to affect women, but collectively attract less attention than they deserve from the public and policy makers.
WHAT SHOULD YOU ASK THE DOCTOR?
Useful information before, during, and after your meeting with your doctor(s)
Brochure from ENGAGe (The European Network of Gynaecological Cancer Advocacy Groups is an ESGO network of European patient advocacy groups representing all gynaecological cancers)
https://engage.esgo.org/brochures/what-should-you-ask-the-doctor/
Recent Advances in Lynch Syndrome Diagnosis, Treatment and Cancer Prevention
Conclusion:
The identification and management of individuals and families with Lynch syndrome has evolved rapidly during the past decade or so. Advances in molecular testing and NGS technologies now allow all patients with colorectal and endometrial cancers to reliably receive screening for underlying Lynch syndrome, whereas innovations in immuno-oncology promise to continue revolutionising the treatment of Lynch-associated cancers.
To continue moving the needle forward, expanded efforts to diagnose Lynch syndrome in healthy, cancer-free individuals are needed, rather than relying on the identification of Lynch syndrome through a new cancer diagnosis.
Identification of Lynch syndrome offers the potential to prevent cancer-related morbidity and mortality, and continued progress in understanding the immune system’s ability to recognize, eradicate, and intercept Lynch-associated neoplasia offers many intriguing possibilities for immune-based primary cancer prevention.
Menopause, Diet and Cancer
This resource is designed to offer practical, evidence-based guidance on how dietary and lifestyle choices can alleviate menopausal symptoms and enhance overall well-being during this unique phase of life. Cancer treatments can sometimes trigger a sudden, intense menopause, often leading to more severe symptoms than those of natural menopause. For some, these symptoms are manageable, while others may find them overwhelming, impacting quality of life.
This book provides support and strategies, covering nutrition and lifestyle modifications to help ease these challenges.
Assessing preventive gynecologic decisions in individuals with Lynch syndrome
Highlights
- Current Lynch syndrome guidelines for managing gynecologic risks are vague and often left to a clinician’s discretion.
- Among 115 patients with intact uterus and/or ovaries upon Lynch diagnosis, 71 (61.8 %) underwent risk-reducing surgery.
- Older age, lower education, completed childbearing, and history of non-gyn cancer were associated with having surgery.
- Patients felt anxiety and frustration with the lack of provider knowledge and support to manage gynecologic cancer risks.
https://www.sciencedirect.com/science/article/abs/pii/S0090825825008297
Lynch Syndrome
Lynch syndrome increases the risk of a number of cancers. In general, the risk is highest for colorectal (bowel) cancer, but it depends on the gene affected.
Some colorectal (bowel) cancers are hereditary. Up to 5 people out of every 100 diagnosed with bowel cancer have Lynch syndrome. Other cancers linked to Lynch syndrome include:
- Endometrial (womb)
- Urothelial (kidney, ureter bladder)
- Ovarian
- Stomach
- Small bowel
- Bile duct/gall bladder
- Brain
- Pancreas
- Prostate
- Skin
Lynch syndrome for the gynaecologist (Nov 2020)
Key content
- Lynch syndrome is an autosomal dominant condition closely associated with colorectal, endometrial and ovarian cancer.
- Women with Lynch syndrome are at increased risk of both endometrial and ovarian cancer and should be offered personalised counselling regarding family planning, red flag symptoms and risk-reducing strategies.
- Surveillance for gynaecological cancer in women with Lynch syndrome remains controversial; more robust data are needed to determine its effectiveness.
- Universal testing for Lynch syndrome in endometrial cancer is being adopted by centres across Europe and is now recommended by the National Institute for Health and Care Excellence; thus, gynaecologists must become familiar with testing strategies and their results.
- Testing strategies involve risk stratification of cancers based on phenotypical features and definitive germline testing.
HSE Health A-Z
Check out new addition on “Lynch syndrome” thanks to NCCP.
Outcomes of endometrial cancer prevention strategies in Patients with Lynch syndrome: a nationwide cohort study.
Female Lynch syndrome carriers have an increased risk of developing endometrial cancer. Regardless, research on endometrial carcinoma tumorigenesis is scarce and no uniform, evidence-based gynaecological management guidelines exist. We therefore described gynaecological surveillance and surgery outcomes in a nation-wide Lynch syndrome cohort.
Interpretation: In a nation-wide cohort of Lynch syndrome carriers, nearly one-third of eligible carriers did not undergo gynaecological surveillance. Endometrial carcinomas diagnosed during surveillance were slightly more often stage FIGO IA, but this did not seem to substantially decrease the requisite for adjuvant therapy or affect overall survival, questioning effectiveness of current gynaecological management. Prospective research should further assess this, as well as patient preferences.
Lynch Choices
- Lynch syndrome is an inherited condition that increases the chance of developing certain cancers. The type of cancer depends on the genes involved.
- This website helps people with Lynch to make choices that are right for them. It is designed to be used with support from the genetics service, GPs, healthcare teams in the community, charities and patient groups.
- If you are concerned about Lynch but have not been diagnosed, please speak to your GP or genetics service.
- You’ll find two sections which help you think about your choices at home, so you are ready to talk through these choices with a GP, genetics or other specialist.
- There are also another six sections providing support and information for people with Lynch. These sections may also be useful to family members and healthcare professionals of people with Lynch.
https://lynchsyndromeireland.wordpress.com/wp-admin/post-new.php
Lynch Syndrome Ireland 