Category: Monitoring

Prevention is better than Cure

Cancer came as no surprise for one survivor.

Learn how the family history and a genetic syndrome put them at high risk.

Delving into the role of genetic counsellors in cancer care.

And the hope for a vaccination.

Lynch Syndrome

Lynch syndrome is an inherited condition that increases the risk of developing certain cancers, including colorectal, endometrial, and ovarian cancer.

On this page

https://www.canceraustralia.gov.au/impacted-by-cancer/lynch-syndrome#what-is-lynch-syndrome

THISISGO.IE

The platform (on-line portal) which was developed ‘by patients for patients’ in partnerships with healthcare professionals, was launched in Sept 2021 and is aiming to change the landscape in how we support those with gynaecological cancers, including cervical, ovarian, endometrial, vulval and vaginal cancers.

Currently there are still significant deficits in the provision of information and support for women affected by gynaecological cancer the team at thisisGO.ie are working, whilst acknowledging the power of cooperation and collection action, to provide this one-stop shop for these women, their families and Health Care Providers via thisisGO.ie

The platform includes articles, videos, podcasts, useful resources, symptom tracker, decoding the science and service directory content. These materials address every stage of the specific cancer diagnosis, treatment and life with and after this cancer. The platform also supports Health Care Professionals in their clinical practice, offering useful articles such as How to Break Bad News and How to take a Sexual History from a Patient.’

thisisGO.ie is kindly supported by the Irish Cancer Society through its Women’s Health Initiative and by UCD Clinical Research Centre (CRC), OvaCare, GSK, Pfizer and patient donations.

Please see https://thisisgo.ie/

What to expect from the NHS Bowel Screening Programme for people with Lynch syndrome

If you live with Lynch syndrome, regular bowel screening is one of the most effective ways to reduce your risk of bowel (colorectal) cancer and catch problems early. The NHS Bowel Cancer Screening Programme has produced a clear, plain-English leaflet, Helping You Decide, to walk you through the offer and help you choose what’s right for you.

Why we offer colonoscopies to people with Lynch syndrome

For people with Lynch syndrome, regular screening by having a colonoscopy has been shown to reduce the chance of becoming seriously ill or dying from bowel cancer, as well as reducing the chance of bowel cancer developing in the first place.

This is because screening through a colonoscopy can detect bowel cancer when it is at an early stage when treatment is more likely to be effective. It can also help to find polyps. These are small growths on the lining of the bowel. Polyps are not cancers but may develop into cancers over time. Polyps can be easily removed, which reduces the risk of bowel cancer developing.

Your clinical genetics team will continue to help you manage your other Lynch syndrome needs and risks (such as gynae and skin checks).

https://www.lynch-syndrome-uk.org/post/nhs-bowel-screening-for-people-with-lynch-syndrome-what-to-expect-and-how-to-decide

Gene-Specific Detection Rate of Adenomas and Advanced Adenomas in Lynch Syndrome

Colonoscopy is expected to reduce colorectal cancer (CRC) incidence in Lynch syndrome (LS) by detecting and removing adenomas. The existence of gene-specific differences in adenoma detection has been proposed yet remains insufficiently explored. This study aims to elucidate gene-specific adenoma detection rates and their association with post-colonoscopy CRC (PCCRC), which stands as an important issue in LS surveillance.

Conclusions

Carriers of MLH1/MSH2 pathogenic variants are at a higher risk of developing advanced adenomas(AAs) compared with those with MSH6/PMS2mutations, with MSH6 carriers exhibiting an intermediate risk profile. AAs are an independent risk factor for PCCRC. LS patients with AAs should be identified as high risk and undergo enhanced colonoscopy surveillance.

https://www.gastrojournal.org/article/S0016-5085(25)00650-X/abstract

Medical misogyny and “harrowing” experiences: what are doctors doing to improve outpatient gynaecological procedures?

Intrauterine procedures for outpatients, such as hysteroscopy, have attracted negative media and parliamentary attention for being poorly tolerated by some women, causing pain and even trauma.

In this BMJ feature, Adele Waters reports on how doctors are tackling the problem.

https://www.bmj.com/content/390/bmj.r1234

Occurrence of dMMR/MSI-H tumor during follow-up in Lynch syndrome patients treated with immune checkpoint inhibitors for metastatic digestive cancer

2015 and 2024: a retrospective analysis of a monocentric prospective cohort study

Highlights

Patients with LS treated with ICIs are at risk of metachronous dMMR/MSI-H cancers (8% of cohort).

The most frequent metachronous(occurring at different times) cancers observed were urothelial cancer and CRC.

Preneoplastic(state or lesion that occurs before the formation of a benign or malignant tumour) colorectal polyps developed in 39% of patients undergoing colonoscopies during follow-up.

Long-term surveillance is critical for LS patients post-ICI treatment.

https://www.esmoopen.com/article/S2059-7029(25)01428-0/fulltext

The Prospective Lynch Syndrome Database (PLSD)

Objective: Compiling existing information on carriers with pathogenic mismatch repair gene variants (path_MMR variants) associated with dominantly inherited cancer.

Aim: Describing associations between the path_MMR variants and cancer in any organ by age, gene and gender, and effects of interventions.

https://www.ehtg.org/plsd.php

New UKCGG gene specific guidance

New UK Cancer Genetics Group(UKCGG) gene specific guidance to incorporate updated advice about risk-reducing aspirin.
For families with Lynch syndrome.

https://www.ukcgg.org/information-education/ukcgg-leaflets-and-guidelines/

Lynch Syndrome UK Conference 2025 -Highlights

Below you’ll find short summaries of each talk, with a link to the YouTube recordings on our YouTube channel, as well as links to additional useful resources at the end.

https://www.lynch-syndrome-uk.org/post/lynch-syndrome-conference-2025-highlights