Today was the day of my annual endoscopies – a flexible sigmoidoscopy, a gastroscopy, and a capsule endoscopy placed via gastroscopy.
Every little win is a win. There’s no point just bouncing onto the next worry, especially if it might never come.
Find joy now, in getting at least one out of three clear tests, and freedom to eat an ice cream sandwich.
https://www.cancer.ie/about-us/cancer-advocacy/prebudget-submission-2025
In the Lynch syndromes (LS) we now recognize a dynamic balance between two stochastic processes: MSI producing abnormal cells, and the host’s adaptive immune system’s ability to remove them.
The latter may explain why colonoscopy surveillance does not reduce the incidence of colorectal cancer in LS, while it may improve the prognosis.
Most early onset colon, endometrial and ovarian cancers in LS are now cured and most cancer related deaths are after subsequent cancers in other organs.
Aspirin reduces the incidence of colorectal and other cancers in LS.
Immunotherapy increases the host immune system’s capability to destroy MSI cancers.
Colonoscopy surveillance, aspirin prevention and immunotherapy represent major steps forward in personalized precision medicine to prevent and cure inherited MSI cancer.
cumulative risks for cancer in organs at increased risks by age, genetic variant, and sex in carriers subjected to colonoscopy.
Version 5 corresponding with PMID: 37181409 and PMID: 37821984.
Based on the observation that removal of adenomas with colonoscopy did not reduce CRC incidence as assumed, in 2012 the European Hereditary Tumor Group (EHTG), at that time denoted the Mallorca Group, decided to compile information on follow-up of path_MMR carriers across multiple specialist centres to answer three questions:
Lynch syndrome is the most common cause of hereditary colorectal and endometrial cancer. Lifestyle modification may provide an opportunity for adjunctive cancer prevention. In this study, they aimed to characterise modifiable risk factors in people with Lynch syndrome and compare this with international guidelines for cancer prevention.
They have characterised the modifiable risk profile of people living with Lynch syndrome, outlining targets for intervention based on lifestyle guidelines for the general population. As evidence supporting the relevance of modifiable factors in Lynch syndrome emerges, behavioural modification may prove an impactful means of cancer prevention.
https://hccpjournal.biomedcentral.com/articles/10.1186/s13053-024-00280-w
Lynch syndrome (LS) is a genetic condition that is passed on between families (inherited). A syndrome is a group of signs and symptoms that occur together and point to a particular condition.
Most people who have Lynch syndrome are well and don’t know they have LS.
However, someone with LS is more at risk of developing certain types of cancer than other people of a similar age.
Family history may not make its way into the EHR at all. Barriers to obtaining a detailed and accurate family history have been well described, and improvements will require system-level strategies such as the genetic education of nongenetics providers, point-of-care risk assessments, interactive patient-facing software, and other solutions.
The EHR can play an important role in identifying candidates for LS screening and advancing the clinical care of patients with LS.
However, many limitations of the EHR need to be addressed and complementary approaches that incorporate input from all stakeholders are key to improving the lives of individuals with LS.
A new NHS testing programme for bowel cancer has been launched for people with Lynch Syndrome, following an initiative to increase genomic testing for the condition.
Around 10,000 people with Lynch syndrome will start receiving invitations to take part this year.
Dr Kevin Monahan, who led the NHS England Lynch syndrome transformation project, said: “Incorporating people with Lynch syndrome into the national colonoscopy screening programme is game-changing and will save many lives each year.
It will deliver prevention and early diagnosis of bowel cancer through timely and high-quality colonoscopy. Now diagnosis of this hereditary condition in England will be linked to lifelong patient-focused care.
“The most challenging part of dealing with Lynch syndrome for me is the uncertainty surrounding my son’s health. The fear of him possibly inheriting the mutation gives me anxiety, especially since he hasn’t been tested yet. If it were solely about me, I might have approached things differently — I may have postponed my prophylactic surgeries until after achieving menopause.”
“I didn’t have to face Lynch syndrome alone after realizing that support is always available. That support system, as well as staying ahead on check-ups and focusing on my wellbeing, guided my path after being diagnosed.”
The landscape of Lynch syndrome has significantly evolved over the past decade, with advancements in genetic testing, universal screening and predictive models improving early detection.
https://www.curetoday.com/view/what-i-wish-i-was-told-about-lynch-syndrome
This rise in colorectal cancer cases among young people has been well-documented in recent years. However, experts are still working to figure out what’s behind the trend.
The myth that someone can be too young to get cancer is just not true.
https://www.health.com/study-colorectal-cancer-rates-children-teens-8648696
Lynch Syndrome Ireland 