Dr Liz Bancroft Lynch Syndrome Annual Conference 2025
an international research initiative investigating targeted prostate cancer (PrCa) screening in men with inherited genetic mutations, specifically those in the BRCA1, BRCA2, and Lynch syndrome genes. The study aims to determine the effectiveness of PSA screening in detecting clinically significant prostate cancer in these high-risk individuals and to compare the findings with a control group of men without the mutations.
When someone hears those words, you have cancer, her world is turned up-side-down, in more ways than one. As is her family’s. I won’t say a cancer diagnosis is necessarily the most horrible thing any person can experience, medically speaking or otherwise, but it’s right up there, that’s for sure.
Once a cancer reaches stage 4, it’s not curable. Treatable, yes. Curable, no.
This is not to say staying positive and fighting hard do not matter. Of course, they do. But cancer outcome is not determined by how hard you fight or how much smiling you do. Cancer isn’t an opponent in some war game you can stomp out with mindset or determination. And a positive attiude—not always doable. Cancer patients don’t need the added pressure to always fight and always stay positive. What does that even mean anyway? It sounds exhausting because it is.
What do you wish you knew then that you know now about your cancer experience?
https://womenofteal.blogspot.com/2025/05/what-i-wish-i-knew.html
Lynch syndrome increases the risk of a number of cancers. In general, the risk is highest for colorectal (bowel) cancer, but it depends on the gene affected.
Some colorectal (bowel) cancers are hereditary. Up to 5 people out of every 100 diagnosed with bowel cancer have Lynch syndrome. Other cancers linked to Lynch syndrome include:
Scope: The scope of the guideline is to provide clinical recommendations on the active surveillance of patients with prostate cancer. Any other treatment was considered to be out of scope.
Summary of National Clinical Guideline
This National Clinical Guideline contains evidence-based recommendations.
This guideline is for patients diagnosed with prostate cancer whose cancer may be suitable for “active surveillance”. Active surveillance is where you watch patient’s cancer closely and only start treatment if test results show it is getting worse. The document explains which patients’ prostate cancer can be managed with active surveillance. It also outlines the tests used to monitor the cancer during active surveillance and how often to get the tests.
It covers:
which patients are suitable for active surveillance enrolment
what type of tests should be included on an active surveillance protocol
how often should patients receive each test on an active surveillance protocol
when should a patient switch from active surveillance to a different treatment
The document also describes the changes in test results that may lead to switching to a different treatment. Ask your doctor or any member of your treating team if you want to know about your test results or treatment options.
Thousands of men are to be checked for prostate cancer in one of the first large-scale European trials of smart screening.
The pilot study, starting next week in Ireland, will combine a blood test with personal risk factors and an MRI scan to increase the accuracy of screening men in their 50s and 60s.
Up to now health experts have rejected population screening in the belief that the benefits of earlier cancer detection were outweighed by the risks that some men could have unnecessary biopsies and risky treatment they don’t need.
But in the Irish pilot study, men will be scored by their PSA level and whether they have other risk factors such as black ethnicity or a family history.
Those at low risk will be retested in future.
30% of patients have an aggressive type of this cancer needing urgent treatment, about 70% have slow-growing cancer and can be monitored without immediate treatment.
This new test was developed out of concerns over-treatment was becoming an issue for men with this type of cancer who may not need treatment.
Biopsy-based MCRS improves risk stratification over standard clinical and pathological information and optimises patient management after diagnosis of prostate cancer.
The PRO-ACT Survey is live! Developed with input from patients, partners, & healthcare professionals, this study explores the impact of prostate cancer treatment on sexual well-being and mental health.
The hope is that the insights gathered will improve care and support for patients in the future.
The findings will identify gaps in current services and communication, helping to develop resources that provide more holistic and effective support.
Patient Survey: https://www.surveymonkey.com/r/YGNKN5T
Partner Survey: https://www.surveymonkey.com/r/2WC2J38
BRCA mutations are inextricably linked with breasts, but they can also lead to cancer in the pancreas, the prostate, and maybe more parts of the body.
As many as 60 percent of men with changes in BRCA2 develop prostate cancer, yet men are generally far less aware than women that BRCA mutations can affect them at all.
Roughly one in 400 people carry a harmful mutation in BRCA1 or BRCA2, and half of them are men. But women are far more likely to have been tested for the mutations—up to 10 times as likely, according to one study.
It’s easy to assume that prostate cancer is a disease that only affects older men. But it can strike at any age, including younger and middle-aged men. Although the average age of diagnosis is 68, about one in ten new cases are in men under 55. In fact, doctors have noticed more cases in younger men in recent years. If you’re in your 40s or 50s, it’s worth knowing about the risks and signs of prostate cancer.
Estimated 1 in 7 at risk thorughout their lifetime.
If you’re worried about any symptoms or about your risk of prostate cancer, don’t hesitate to talk to your doctor. Being proactive about your health is important. Remember, many men diagnosed with prostate cancer go on to live long, full lives, especially when it’s caught early.
https://www.rte.ie/brainstorm/2024/1111/1480273-prostate-cancer-risks-signs-symptons-mri-scan/
Lynch Syndrome Ireland 