Author: Lynch Syndrome Ireland

Lynch syndrome: from detection to treatment

Conclusion

Lynch syndrome is encountered by many clinicians at some stage in their practice and yet remains under-diagnosed with historically limited success in risk stratification and management.

The PLSD international database continues to expand our knowledge of LS-associated cancer risk. However, we have yet to obtain international consensus on the optimal surveillance strategies, which will be essential among a population of patients who are living beyond their index cancer. The advent of NGS into clinical practice will undoubtably improve detection rates and allow for more effective, precise, and personalised management programmes for patients with LS.

Over the next decade it will be exciting to see improvements in the preventative strategies that can be offered to patients in the form of aspirin, or even anti-cancer vaccines, as we continue to attempt to disrupt the natural history of this prevalent cancer predisposition syndrome.

https://www.frontiersin.org/articles/10.3389/fonc.2023.1166238/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FONC_XXXXXXXX_auto-dlvrit#h6

What is MY Cancer Risk? Lynch Syndrome Explained: And How to Get Tested

To better understand Lynch syndrome and how to test for it early, we sat down with Dr. Michael Hall, a medical oncologist at Fox Chase Cancer Center. In this conversation, he discusses Lynch syndrome, what cancers patients would be more at risk for, and who should get tested.

Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations

CONCLUSIONS

Despite the efficacy of premenopausal RRSO for reducing ovarian cancer risk and improving mortality in high-risk women, many women experience troublesome menopausal symptoms and oophorectomy may have adverse implications for long-term health.

Our panel of international experts has developed evidence-based recommendations for managing vasomotor, sleep, mood, sexual, and genitourinary symptoms and optimising bone and cardiovascular long-term health. Emerging evidence suggests that HRT reduces but does not eliminate the adverse effects of premenopausal oophorectomy. Women and clinicians considering RRSO should be aware of these risks and clinical care should focus on available safe options for symptom management and optimisation of long-term health.

https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.17511

Lynch Syndrome: A Single Hereditary Cancer Syndrome or Multiple Syndromes Defined by Different Mismatch Repair Genes?

it may be appropriate to consider categorizing Lynch syndrome as 4 distinct syndromes based on the specific altered MMR gene, as occurs for the recessive syndromes associated with MUTYH, NTHL1, and MBD4base excision repair glycosylases. The varying carcinogenic mechanisms and associated cancer risks indicate the need for gene-specific surveillance recommendations in Lynch syndrome. Moreover, the growing understanding of gene-specific differences will likely affect treatment options and efficacy of Lynch syndrome vaccines.

https://pubmed.ncbi.nlm.nih.gov/37142200/

Nurses in 26 cancer treatment centres proving a valuable resource

Covid silver lining: Establishment of countrywide network to help chemo patients set for 24/7

Until a few years ago, cancer patients at home and receiving chemotherapy or other therapies had few options. Their default was to head for their local hospital emergency department (ED), there to face long delays and the risk of cross-infection from other patients waiting to be seen.

The service, introduced during an emergency when it was vitally important to keep EDs free for Covid patients and to keep vulnerable patients with other conditions away from a new virus, has proved to be a resounding success.

https://www.irishtimes.com/health/2023/04/24/nurses-in-26-cancer-treatment-centres-proving-a-valuable-resourse/

GE Notes – Lynch Syndrome

Genomic Notes for Clinicians

Page contents:

https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/lynch-syndrome/

Lynch Syndrome information

It covers the following:

Lynch Syndrome information

Is There a Lynch Syndrome Vaccine on the Way?

Lynch Syndrome, a genetic condition affecting around 1 million Americans annually, increases a person’s risk of developing colorectal cancer (CRC) to 20% – 80%.

As a result, Lynch Syndrome patients must complete yearly preventive screenings. However, developing a Lynch Syndrome vaccine could change the narrative for patients, reducing screenings and – more importantly – lowering risks for Lynch Syndrome-related cancers. 

“The advances in vaccine technologies, such as Lynch Syndrome, is a promising field of research that has the potential to reduce the risk of developing cancer, thereby preventing disease and modifying surveillance regimens for high-risk patients,” said David Fenstermacher, Senior Director of Research & Medical Affairs at the Colorectal Cancer Alliance.

https://www.ccalliance.org/blog/research/is-there-lynch-syndrome-vaccine

Carpe Diem A Little Harder After a Skin Cancer Scare

“…this lesion was positive for “the ugly duckling” sign as it was significantly darker than my other moles”

https://www2.curetoday.com/view/carpe-diem-a-little-harder-after-a-skin-cancer-scare

Lynch Syndrome

Key Points

  •  Lynch syndrome is a rare, inherited condition that increases your risk of developing bowel cancer and sometimes other cancers. 
  • Lynch Syndrome accounts for about 3% of all bowel cancer.  
  • Regular bowel screening by colonoscopy can prevent bowel cancers developing.  
  • Bowel Screening usually starts from the age of 25 years and is performed on a yearly basis.  
  • People with Lynch Syndrome are also at increased risk of developing certain other cancers such as uterine (womb), urinary tract, ovary and small bowel.  
  • Women should consider screening of the uterus and ovaries from the age of 30-35 years.  
  • Genetic testing is available for families with this syndrome.  
  • When you have Lynch Syndrome, each of your children have a 1 in 2 (50%) chance of inheriting it.  

https://www.nzfgcs.co.nz/Syndromes/Lynch-Syndrome