The study, which was published in the Journal of the National Cancer Institute, found that there are four symptoms that can be early warning signs for colorectal cancer:
According to the study, these symptoms appeared at least two years before a colorectal cancer diagnosis.
Lynch syndrome is encountered by many clinicians at some stage in their practice and yet remains under-diagnosed with historically limited success in risk stratification and management.
The PLSD international database continues to expand our knowledge of LS-associated cancer risk. However, we have yet to obtain international consensus on the optimal surveillance strategies, which will be essential among a population of patients who are living beyond their index cancer. The advent of NGS into clinical practice will undoubtably improve detection rates and allow for more effective, precise, and personalised management programmes for patients with LS.
Over the next decade it will be exciting to see improvements in the preventative strategies that can be offered to patients in the form of aspirin, or even anti-cancer vaccines, as we continue to attempt to disrupt the natural history of this prevalent cancer predisposition syndrome.
Despite the efficacy of premenopausal RRSO for reducing ovarian cancer risk and improving mortality in high-risk women, many women experience troublesome menopausal symptoms and oophorectomy may have adverse implications for long-term health.
Our panel of international experts has developed evidence-based recommendations for managing vasomotor, sleep, mood, sexual, and genitourinary symptoms and optimising bone and cardiovascular long-term health. Emerging evidence suggests that HRT reduces but does not eliminate the adverse effects of premenopausal oophorectomy. Women and clinicians considering RRSO should be aware of these risks and clinical care should focus on available safe options for symptom management and optimisation of long-term health.
https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.17511
Covid silver lining: Establishment of countrywide network to help chemo patients set for 24/7
Until a few years ago, cancer patients at home and receiving chemotherapy or other therapies had few options. Their default was to head for their local hospital emergency department (ED), there to face long delays and the risk of cross-infection from other patients waiting to be seen.
The service, introduced during an emergency when it was vitally important to keep EDs free for Covid patients and to keep vulnerable patients with other conditions away from a new virus, has proved to be a resounding success.
Genomic Notes for Clinicians
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https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/lynch-syndrome/
Spring has officially sprung but that doesn’t mean we can’t sit down and enjoy some tasty and healthy tomato soup! Head over to our website for the full FREE cookbook, designed and written by registered dietitians!
mRNA Covid vaccine technology could be repurposed so that it primed the immune system to attack cancer cells.
BioNTech was working on mRNA cancer vaccines before the pandemic struck but the firm pivoted to produce Covid vaccines in the face of the global emergency. The firm now has several cancer vaccines in clinical trials. Türeci said the development and success of the Pfizer/BioNTech vaccine, which is similar to the Moderna Covid shot, “gives back to our cancer work”.
But Türeci(who co-founded BioNTech, the German firm that partnered with Pfizer to manufacture a revolutionary mRNA Covid vaccine) remained cautious about the work. “As scientists we are always hesitant to say we will have a cure for cancer,” she said. “We have a number of breakthroughs and we will continue to work on them.”
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