Category: Research

Patients, Bowels, Basics and Breakthroughs

Very excited to share that @rcsi_irl ‘Patients, Bowels, Basics and Breakthroughs’ is back!!!

This two day event is aimed at bringing together the patient & professional community to explore the landscape of bowel cancer, with focus on the unique challenges of early-onset disease like fertility, sexual health and much more!

Learn about the latest research directly from those carrying out the work! It will feature fantastic speakers from across Ireland, the UK and Europe and powerful patient voices sharing their lived experiences.

There’ll be exciting panel discussions, a poster session and even a lab tour! 

What makes this event even more special is the people behind it. The fabulous (and I mean fabulous!) RCSI Epigastro Disease Research Group who have opened their doors to ourselves at @lynchsyndromeireland & @BowelCancerIreland and welcomed us as valued team members to co-organise these important events. This is more than patient involvement this is true PPI partnership. Together we can do more.

This free event is open to patients and their family members, carers, healthcare professionals and members of the public who would like to learn more about this very common cancer. 

When: 11 & 12 September 2025

Where: RCSI St Stephens Green Dublin 

Registration is essential. Scan the QR code on poster to register today. Please share the event with anyone who you feel would benefit or be interested.  

Let’s talk about bowel cancer, let’s do it all together!

#bowelcancer #CancerResearch #PPI#EOCRC

Cancer Revolution Exhibition

WHAT YOU’LL DISCOVER
  • Real stories from people affected by cancer
  • Groundbreaking science that’s shaping the future of treatment
  • Interactive exhibits that let you explore how cancer works
  • The surprising truth about prevention, early detection, and personalised treatment
  • Hope – through the power of research

https://breakthroughcancerresearch.ie/cancer-revolution/

#Cancer Revolution

If you are in Dublin over the coming weeks, please call to @BreakthroCancer#CancerRevolution exhibition which opens today.

Read the inspiring stories, get to see what is being done in #research.

1/2 of us will get a #cancer diagnosis

Randomised Trials and Their Role in Modern Healthcare!

A free online course in Randomised Trials and Their Role in Modern Healthcare! – No prior knowledge needed – At your own pace and takes approximately 5 hours – This course is free to access on FutureLearn Learn more/enrol at:

https://www.futurelearn.com/courses/randomised-trials-and-their-role-in-modern-healthcare

Gene-Specific Detection Rate of Adenomas and Advanced Adenomas in Lynch Syndrome

Colonoscopy is expected to reduce colorectal cancer (CRC) incidence in Lynch syndrome (LS) by detecting and removing adenomas. The existence of gene-specific differences in adenoma detection has been proposed yet remains insufficiently explored.

Conclusions

Carriers of MLH1/MSH2 pathogenic variants are at a higher risk of developing AAs compared with those with MSH6/PMS2 mutations, with MSH6 carriers exhibiting an intermediate risk profile. Advanced adenomas(AA) are an independent risk factor for post-colonoscopy CRC . LS patients with AAs should be identified as high risk and undergo enhanced colonoscopy surveillance.

https://www.sciencedirect.com/science/article/abs/pii/S001650852500650X?dgcid=author

Study: Two immunotherapy drugs are better than one for some metastatic colorectal cancers

Combining two immunotherapy drugs is a more effective treatment for certain metastatic colorectal cancers than using either treatment drug alone.

CheckMate 8HW trial used together, Opdivo (nivolumab) plus Yervoy (ipilimumab) slowed cancer growth in MSI-High metastatic colorectal cancers, a type of colorectal cancer often found in Lynch syndrome.

The FDA approved this combined treatment for MSI-High metastatic colorectal cancer after progression with chemotherapy.

Note: People with Lynch syndrome who have colorectal cancer commonly have MSI-H or dMMR cancers.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02848-4/abstract

Preventing Ovarian Cancer: Living With Consequences

Key Takeaways:
  • Lynch syndrome can necessitate early oophorectomy, leading to abrupt surgical menopause and significant health impacts due to sudden estrogen loss.
  • Estrogen plays a crucial role in protecting bones, joints, brain, heart, and emotional well-being, with its absence exacerbating conditions like osteoarthritis and cardiovascular disease.
  • The narrative calls for broader menopause discussions, including the experiences of women undergoing early surgical menopause, and emphasizes the need for more research and nuanced care.
  • The author stresses the importance of managing chronic conditions and mental health post-surgery, advocating for better support and understanding for women facing similar challenges.

https://www.curetoday.com/view/preventing-ovarian-cancer-living-with-consequences?fbclid=IwY2xjawLxciJleHRuA2FlbQIxMABicmlkETB6S0xyT01CVGNNS3pubzNoAR55anv9w480ijD0-9z9uyhoKUcimZWF2FOXBw3KaopIo4QZXQ7C83om8K4goQ_aem_ApoJirQV0HbAzrqG8nUxYA

Cancer Revolution: Science, Innovation and Hope – Aug 15th to Sept 5th (Free Event)

Through seldom and never-before seen objects and stories, cutting edge treatment and research, reflection, film, photography, interactive exhibits and a breadth of personal stories – this exhibition presents the stories of people affected by cancer, together with those who study and treat it. Revealing how researchers, clinicians, policy makers and patients are fuelling progress in a powerful expression of shared hope.

Shaped through collaboration with people living with and impacted by cancer, the exhibition will take visitors on a journey of discovery with scientists, clinicians and people who have been affected by cancer in their own words. Explore everything known so far about what cancer is and what causes it, why scientists are focusing their research on understanding how and why cancer evolves, and what the future of cancer care looks like.

The exhibition reveals how cancer has been treated over the centuries, from high-risk surgeries to the discovery of the first chemotherapy drugs, and the important challenges that remain to be solved.

How Cancer Spreads: Four Emerging Insights About Metastasis

https://www.mskcc.org/news/how-cancer-spreads-four-emerging-insights?utm_source=X&utm_medium=Organic+Social&utm_term=&utm_content=Image+of+Dr.+Massagué&utm_campaign=Social+Media+Posts+July+2025

“Metastasis used to be an automatic death sentence, but that is no longer the case,” he says. “In some cases, it is now curable with immunotherapy, and for many cancers it is becoming more controllable. We are probably never going to eliminate it — but we are moving closer and closer to being able to prevent it in some cases, and to manage it the same way we manage other chronic diseases.”

Bowel Cancer in Ireland: Event

PATIENTS, BOWELS, BASICS, AND BREAKTHROUGHS

SEPTEMBER 11TH 2025: 3PM-6PM SEPTEMBER 12TH 2025: 10AM-6PM