Category: Screening

Lynch Syndrome and me: Leanne’s story

“There are two things I want people to know. Firstly, the understanding about LS at all the different touch points in the NHS is amazing. Secondly, having LS isn’t necessarily a bad thing. I have the MSH2 variant. It’s not great to know all the associated risks, but it gives me the opportunity to better both my and my family’s future chances. It’s a blessing in disguise to discover this.”

“When we found out, we spoke with other family members as I felt that I needed to let them know. Some of my relatives came forward and got themselves tested to see if they could make the same informed decisions; others didn’t.”

Having this knowledge has enabled me to make decisions about my life.

Mainstreaming. Cancer Test: Predisposition to cancer

Check out RTE Nine O Clock News…starts at 11.30 min. into programme.

https://www.rte.ie/player/series/rté-news-nine-o-clock/SI0000001468?epguid=IH10000961-23-0182

See recently launched National Hereditary Cancer Model of Care (NCCP)

Why do GPs need to know about Lynch syndrome?

Find out during

@kevinjmonahan‘s talk at

@PULSE365_Hub on 6 July. This virtual conference gives you a brilliant selection of talks to choose from – find out more: https://bit.ly/3qUTLnl#generalpractice#primarycare

Lynch Syndrome Booklet -Eve Appeal(UK)

Lynch Syndrome and understanding your options

People with Lynch Syndrome are at a higher risk than the general population of developing some cancers. Identifying people who have Lynch Syndrome can have important benefits, including prevention of cancer, spotting it early and helping doctors decide on the best treatment for people who do develop cancer.

This booklet aims to help you understand more about the syndrome, what your options are…

Click to access Lynch-Syndrome_Patient-guide_vs2_digital_FINAL_21.02.23.pdf

Lynch Syndrome: A Single Hereditary Cancer Syndrome or Multiple Syndromes Defined by Different Mismatch Repair Genes?

The risks of cancer (cumulative risks for various cancer types) differ among Lynch syndrome patients based on the specific altered MMR gene.

It may be appropriate to consider categorising Lynch syndrome as 4 distinct syndromes based on the specific altered MMR gene.

The varying carcinogenic mechanisms and associated cancer risks indicate the need for gene-specific surveillance recommendations in Lynch syndrome.

Moreover, the growing understanding of gene-specific differences will likely affect treatment options and efficacy of Lynch syndrome vaccines.

Studies of larger sample series are needed to definitively confirm the differences in mutational features identified across Lynch syndrome tumors and to evaluate the associated clinical consequences.

https://www.gastrojournal.org/article/S0016-5085(23)00696-0/fulltext

Finding the missing 95%: The Lynch syndrome diagnostic pathway to mainstreaming: NHS

Workshop to hear about the diagnostic pathway all the way to mainstreaming genetic testing & setting-up new clinics.

https://www.norththamesglh.nhs.uk/lynch-syndrome-pathway-mainstreaming/

Hereditary Cancer Model of Care launched yesterday in Ireland

This provides the blueprint for the necessary development of hereditary cancer services in Ireland.

Lynch syndrome quick guide for Primary Care clinicians

Click to access Lynch-quick-guide-for-GP-Feb-2022.pdf

7 things men should know about genetic testing and cancer

While the cause of most cancers is unknown, about one in 10 cancers are caused by changes in genes that can be passed down in families.

The lifetime risk of developing colorectal cancer is up to 52% for people with a gene mutation associated with Lynch syndrome, compared to about 4% for the general population.

These people also tend to get cancer at an earlier-than-average age. It’s estimated that less than 10% are aware of their status.

#MensHealthWeek