Blog

SURVIVOR GUILT

Survivor guilt is common in Cancer Land.

Sometimes, you wonder why you’re still here when so many others, often with similar initial diagnoses to yours, are not. Adding guilt into the crapshoot is unhelpful and unnecessary. Nonetheless, add it in we do.

Results of phase I-II bridging study for Nous-209, a neoantigen cancer immunotherapy, in combination with pembrolizumab as first line treatment in patients with advanced dMMR/MSI-h colorectal cancer.

https://ascopubs.org/doi/abs/10.1200/JCO.2023.41.16_suppl.e14665

Conclusions: The combination of Nous-209 and pembrolizumab is safe, well tolerated and shows encouraging clinical efficacy in patients with treatment-naive dMMR/MSI-H mCRC eligible for anti-PD-1 therapy.

The study is ongoing and expanding to Phase II randomisation with a new accelerated Nous-209 vaccination schedule.

Aging After Oophorectomy

“In navigating the effects of accelerated aging post-oophorectomy, HRT can be an essential tool for those who have not achieved menopause. While it can alleviate various symptoms and health risks, it is crucial to discuss its potential benefits and drawbacks with a healthcare provider.”

https://www.curetoday.com/view/aging-after-oophorectomy

Improving Doctor, Patient, and Caregiver Communication

There is a great deal to be gained by improving communication between patients, family caregivers, and healthcare professionals — especially physicians. Better care for patients, less stress for caregivers, more efficient use of doctors’ time, and improved satisfaction for all concerned can be achieved when caregivers and patients communicate effectively with their care team.

Doctors at MSK are learning how to talk to patients, caregivers, and peers through their Communication Skills Research & Training (COMSKIL) program.

In this webchat, MSK experts will discuss how patients and caregivers benefit from this training, as well as how you can use communication techniques, research, and information from the program when talking to your doctors and loved ones.

Exploring Stakeholders’ Perspectives on Implementing Universal Germline Testing for Colorectal Cancer: Findings From a Clinical Practice Survey

CONCLUSION: This study(Eighty CGA-IGC members participated) demonstrates wide support among hereditary GI cancer experts for implementation of UGT for patients with CRC. However, alternative service delivery models using nongenetics providers should be considered to address the logistical barriers to UGT implementation, particularly the growing demand for genetic testing.

In conclusion, there is broad support for UGT for all newly diagnosed patients with CRC among the members of the CGA-IGC.

However, changes to practice, such as alternative service delivery models or standardization of test choice, will likely have to be implemented to meet the increased patient volume.

Additional studies are needed to compare UGT implementation strategies (eg, traditional or alternative service delivery models) to ensure there is equitable access to genetic testing and improved outcomes for patients with CRC.

https://ascopubs.org/doi/full/10.1200/PO.23.00440

The ins and outs and ups and downs of a colonoscopy

So what is a colonoscopy?

A colonoscopy is a test to look at your bowel using a small camera. The test looks for any small growths called polyps, or signs of disease, such as bowel cancer. If polyps are found they are usually removed during the test. This will reduce the risk of cancer developing. If they are not removed they might turn into cancer. If bowel cancer is found early, it’s easier to treat and there’s a better chance of recovery.

https://bit.ly/3lWzc80

(thisisGO.ie) is an online personalised resource for you and yours who have been impacted by a gynaecological cancer.

Phase 1 was launched on September 20th 2021.  It is a personalised
online resource for women impacted by cervical cancer.
If you have a partner in your life, this platform can also support them. If you are a health care provider working in the area this can also support you and your
practice. 

If you are newly diagnosed, receiving treatment, in surveillance
or living well with and beyond cancer thisisGO.ie has information that is
tailored to meet your needs.

During 2022 the remaining 4 gynaecological cancers Ovarian, Uterine, Vulval and Vaginal were launched as well as the addition of a genetic pathway for those impacted by BRCA and Lynch Syndrome. 

Red flags for colorectal cancer in young adults

https://www.facingourrisk.org/XRAY/red-flags-for-colorectal-cancer-in-young-adults

Researchers were able to identify the following four signs that occurred more often in the group of patients with colorectal cancer compared to the group without colorectal cancer: 

  • rectal bleeding (which may be seen in stool)
  • pain in the abdomen (belly)
  • diarrhea
  • anemia (not having enough red blood cells to carry oxygen to tissues), which is found by a blood test

While these symptoms might be due to other underlying conditions, it is important not to ignore these symptoms if they continue. Among these four signs, rectal bleeding was most commonly associated with developing colorectal cancer.

Genetic testing and the future of medicine

More common signs of hereditary cancer include:

  • Multiple cases of cancer on the same side of the family, especially breast, colorectal, endometrial or ovarian cancers.
  • Cancer diagnosed before age 50, especially breast, colorectal or endometrial.
  • Rare cancers at any age, including:
    • ovarian
    • pancreatic
    • male breast
    • metastatic prostate

The future of genetic testing

Dr. Steiner is optimistic about the future of genetic testing and how it can impact healthcare care. “I think in the not-too-distant future, everybody will have comprehensive genetic testing done in order to prepare healthcare providers for any future issues a patient might develop.”

When that happens, genetic testing will be used more often to help people and their healthcare providers prevent unexpected diagnoses.

https://www.facingourrisk.org/XRAY/genetic-testing-and-future-of-medicine