“Ireland’s small population offers an opportunity to identify all those with Lynch Syndrome (LS) in the country, which would represent a powerful preventive opportunity to meaningfully impact on the incidence of cancer in Ireland.”
AGA Guidelines: A helpful tool for your GI doctor
According to the American Gastroenterological Association (AGA), all colorectal cancer patients should undergo tumor testing to see if they carry Lynch syndrome, the most common inherited cause of colorectal cancer, according to a new AGA guideline. They have provided an excellent resource for GI doctors on how to go about testing individuals with colorectal cancer for Lynch syndrome, as well as how to manage their screening if they do have Lynch syndrome. If you have recently been diagnosed with colon cancer or have a diagnosis of Lynch syndrome please print this PDF and take it to your GI doctor or GI Oncologist to be sure you are getting the right testing and management for colon cancer associated with Lynch syndrome.
AGA Guideline on the Diagnosis and Managment of Lynch Syndrome
What is Lynch Syndrome? (Thanks to Sir John Burn Lynch Syndrome UK Conference 2015)
We all inherit our DNA 50% from each parent. If we have LS then one of our repair genes is good while the other one is faulty.
Think of the repair genes as two Doormen on the door at a night club. Nothing is going to get past them that shouldn’t. This is a person without LS
Imagine one of the Doormen needs the toilet and walks off. We still have one doorman watching and keeping us safe. This is a person with LS
Imagine the other doorman now needs to toilet and leaves. Nobody is now watching door. This is what happens when one good gene goes faulty for what ever reason. Anybody can just walk in now
In brief, we only have one repair gene looking out for us and if it gets damaged in a cell we are left with no protection.