Lynch syndrome patients are at high risk of CRC despite regular endoscopic surveillance.
Conclusion: First data suggesting that real-time AI-assisted colonoscopy is a promising approach to optimise endoscopic surveillance in LS patients, in particular to improve the detection of flat adenomas.
Due to the increasing complexity of genomic data interpretation, and need for close collaboration with clinical, laboratory, and research expertise, genomics often requires a multidisciplinary team (MDT) approach.
Most cancer is not inherited in families and occurs sporadically, as a result of random changes in our cells over time. However, approximately 10% of cancer is hereditary and is due to a genetic mutation that has been passed down in the family, increasing the risk for certain cancers to develop.
https://www.cgaigc.com/post/hereditary-cancer-red-flags-and-how-it-impacts-screening
(Neoadjuvant: First step to shrink a tumour before the main treatment)
The modern management of rectal cancers continues to evolve.
With the release of data from new landmark randomized controlled trials (RAPIDO, PRODIGE-23), total neoadjuvant therapy (TNT) has moved to the forefront of locally advanced rectal cancer treatment and is considered a standard option in selected patients.
Surgeons have a fundamental role in the treatment of patients with rectal cancer. Although neoadjuvant or adjuvant treatments certainly can improve outcomes, definitive curative-intent treatment still depends on complete surgical resection as standard therapy.
A personalised online resource for women impacted by cervical cancer. If you have a partner in your life, this platform can also support them. If you are a health care provider working in the area this can also support you and your
practice.
If you are newly diagnosed, receiving treatment, in surveillance
or living well with and beyond cancer this has information that is
tailored to meet your needs.
Also information on Ovarian, Uterine, Vulval and Vaginal cancers.
In addition a genetic pathway for those impacted by BRCA and Lynch Syndrome.
People with Lynch syndrome may develop polyps, which can vary in size. Colon polyps are very common and most are harmless. But if they are left untreated, they can lead to cancer.
If one of our parents has Lynch syndrome, at the point of conception, they have a 50% chance of passing on their altered copy and 50% chance of passing on their unaltered copy. If a person inherits the altered copy, they will have Lynch syndrome.
The Lynch syndrome genes are like police officers in our body, checking that cells know when to stop dividing and do not turn into cancer cells, and by doing so they protect us against cancer. If these genes aren’t working properly, this might result in fewer police officers protecting us against cancer.
For bowel cancer, survival is strongly related to stage at diagnosis: 9 in 10 people will survive if diagnosed at the earliest stage, because they’re more likely to be offered curative treatment. However, treatment is less effective and therefore survival is lower as the disease progresses.
The new national Lynch syndrome colonoscopy programme will be delivered by the national Bowel Cancer Screening Programme. This will have a transformative effect on the care of people with Lynch, improving their experience as well as the prevention and early diagnosis of bowel cancer. It’s estimated 300 lives could be saved every year if diagnosis and optimal care for Lynch syndrome are offered in England.
The change to the surveillance programme will ensure:
Moving the Lynch surveillance within the national screening programme is the first screening programme of its kind in the world.
Genetic counselling is still a developing profession in Europe and this historical and current view of the European genetic counsellor pathways, allows for educational and professional standards to be examined as the profession evolves into the future.
How are we doing in Ireland ????@bernardgloster
https://pubmed.ncbi.nlm.nih.gov/38355960
https://www.sciencedirect.com/science/article/pii/S1769721223000162#sec5
This study may also contribute to strengthening the professional role and standards of genetic counsellors in many countries, as well as identifying the necessary mechanisms for the successful implementation of counselling supervision
Please click on the links to access guidelines and leaflets created by UKCGG, CanGene-CanVar working groups and expert colleagues.
Additional guidelines from other expert groups are available.
Patients with certain heritable cancer predisposition syndromes may benefit from referral to their local Polyposis Rare Disease Collaborative Centre working in the relevant Rare Disease Collaborative Network (RDCN).
Lynch Syndrome Ireland 