Category: Uncategorized

So how would I like to change healthcare? Part 3 of 3

Doctor, please……GetPersonal with me!

Improving Doctor, Patient, and Caregiver Communication

There is a great deal to be gained by improving communication between patients, family caregivers, and healthcare professionals — especially physicians. Better care for patients, less stress for caregivers, more efficient use of doctors’ time, and improved satisfaction for all concerned can be achieved when caregivers and patients communicate effectively with their care team.

Doctors at MSK are learning how to talk to patients, caregivers, and peers through their Communication Skills Research & Training (COMSKIL) program.

In this webchat, MSK experts will discuss how patients and caregivers benefit from this training, as well as how you can use communication techniques, research, and information from the program when talking to your doctors and loved ones.

Screening and testing practices for Lynch syndrome in Nova Scotians with endometrial cancer: a descriptive study

Identifying affected people is crucial to cancer management and in providing risk-reducing strategies for them and their affected relatives.

Results: They identified 465 people diagosed with endometrial cancer during the study period. Most were aged 51 years or older, and had obesity and low-grade early-stage endometrioid tumours. Tumour immunohistochemistry testing was performed in 444 cases (95.5%). Based on local criteria, 189 patients were eligible for genetic counselling, of whom 156 (82.5%) were referred to medical genetics. Of the 98 patients who underwent germline testing, 9 (9.2%) were diagnosed with Lynch syndrome.

Screening and testing practices for Lynch syndrome in Nova Scotians with endometrial cancer: a descriptive study
Screening and testing practices for Lynch syndrome in Nova Scotians with endometrial cancer: a descriptive study

Lynch Syndrome Patient Information Evening 2023

Register on Eventbrite

Advances in vaccine development for cancer prevention and treatment in Lynch Syndrome

https://doi.org/10.1016/j.mam.2023.101204

Highlights

  • •Tumors from Lynch syndrome patients have high mutation and neoantigen burden, which leads to high infiltration of T-cells.
  • •Certain tumor neoantigens are shared among Lynch syndrome patients due to mutations recurring in prone microsatellite loci.
  • •Several in silico tools have emerged to predict neoantigens and their immunogenicity from next-generation sequencing data.
  • •Lynch Syndrome patients are a defined and prevalent population with potential to benefit from cancer immune-interception.
  • •Neoantigen-based vaccines hold promise for the treatment and potential prevention of mismatch repair deficient cancers.

Do You Ever Feel Like a Cancer Misfit?

Do You Ever Feel Like a Cancer Misfit?

When your doctor doesn’t listen — 10 tips to help change that.

When Your Doctor Doesn’t Listen — 10 Tips to Help Change that

Lynch Syndrome: A Single Hereditary Cancer Syndrome or Multiple Syndromes Defined by Different Mismatch Repair Genes?

it may be appropriate to consider categorizing Lynch syndrome as 4 distinct syndromes based on the specific altered MMR gene, as occurs for the recessive syndromes associated with MUTYH, NTHL1, and MBD4base excision repair glycosylases. The varying carcinogenic mechanisms and associated cancer risks indicate the need for gene-specific surveillance recommendations in Lynch syndrome. Moreover, the growing understanding of gene-specific differences will likely affect treatment options and efficacy of Lynch syndrome vaccines.

https://pubmed.ncbi.nlm.nih.gov/37142200/

GE Notes – Lynch Syndrome

Genomic Notes for Clinicians

Page contents:

https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/lynch-syndrome/