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HRCI 2023 Position Paper – Embedding research in healthcare

“While there are many aspects of health research in need of attention and support, we believe it is particularly urgent to support the embedding of research within the health service.“

To this end, we lay out three recommendations:

Recommendation 1    Progress the implementation of a national electronic health record  

Recommendation 2    Build on momentum to support genetics and genomics research  

Recommendation 3    Establish research support functions within the health service

https://drive.google.com/file/d/1I14EY8MdChGaui6w5iXHU5oxrPuS_C7i/view

The NordICC Trial: The Devil Is in the Details

The NordICC trial was a randomized, pragmatic study that enrolled 84,585 adults aged 55 to 64 years old from Poland, Norway, and Sweden.

[T]he NordICC trial … fills an important knowledge gap and provides new insight into the real-world population-wide benefit of colonoscopy for colorectal cancer screening.

Preventing Colorectal Cancer

It is important to highlight an advantage of colorectal cancer screening that distinguishes it from all other cancer screening modalities. Colorectal cancer screening with endoscopy is unique in that it aims to, in part, prevent disease by identifying and removing premalignant lesions.

https://ascopost.com/news/november-2022/the-nordicc-trial-the-devil-is-in-the-details/

Medical gaslighting: ‘No man would be asked if they suffer from panic attacks while having a heart attack’

Women are more likely to feel their symptoms are not being taken seriously by doctors. Why?

“Medical gaslighting” is a controversial term that has emerged to describe a phenomenon some people – women in particular – may recognise. It refers to a patient’s feeling that their symptoms are not taken seriously, or are being misdiagnosed by healthcare professionals.

Now researchers are interested in understanding why this is, and whether gender stereotyping might play a role. Are doctors more likely to attribute pain or exhaustion in women to non-physical causes such as stress?

https://www.irishtimes.com/health/2023/01/28/medical-gaslighting-no-man-would-be-asked-if-they-suffer-from-panic-attacks-while-having-a-heart-attack/

Person-based co-design of a decision aid template for people with a genetic predisposition to cancer

https://www.frontiersin.org/articles/10.3389/fdgth.2022.1039701/full

Conclusion: Adopting a co-design process helped ensure that the decision aid components were relevant and accessible to the target population. The template could have widespread application through being adapted for different genetic predispositions. The exact content should be co-designed with people from diverse backgrounds with lived experience of the specific predisposition to ensure it is as useful, engaging and relevant as possible

Lifestyle, genetic risk and incidence of cancer: a prospective cohort study of 13 cancer types

Conclusions:

The recommended lifestyle has beneficial associations with most cancers. In terms of absolute risk, the protective association is greater for higher genetic risk groups for some cancers. These findings have important implications for persons most genetically predisposed to those cancers and for targeted strategies for cancer prevention.

https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyac238/6990971?login=false&fbclid=IwAR292N2A3C-zRXHNdg969dY_gR27FgaT7BpZz1Jtx6lr0pRDQVg5h5hzwI0

She With Lynch Syndrome

“The future is bright for those of us with Lynch syndrome and, most likely, for most of us with a hereditary cancer syndrome.“

She and all of the new medical advances for those with Lynch syndrome give me hope for if and when I ever develop cancer. 

https://www.curetoday.com/view/she-with-lynch-syndrome

A Focused Clinical Review of Lynch Syndrome

In summary, LS care has come a long way over the last twenty years. We now understand the individual cancer risk to inform consent, tests to accurately diagnoses LS and ways by which we can reduce cancer risk.

However, more needs to be done to find those who are undiagnosed, develop less invasive cancer surveillance methods and develop new vaccinations and treatments.

https://www.dovepress.com/a-focused-clinical-review-of-lynch-syndrome-peer-reviewed-fulltext-article-CMAR?fbclid=IwAR33GEIsS9fAA63cUmvwRtWTrGALZ2a74tovR7JMBPYNVjDdsx_dDun9oMQ

Lynch Syndrome and the Risk of Ovarian Cancer

Lynch syndrome increases the risk of many different types of cancer, including ovarian cancer. The exact level of risk depends on which gene contains the mutation.

Overall, ovarian cancer is rare. The American Cancer SocietyTrusted Source estimates that 1 in 78 (1.2%) of people with ovaries will develop ovarian cancer during their lifetime. Additionally, more than half of people receive a diagnosis at age 63 or older.

In contrast, people with Lynch syndrome have a 3% to 17% lifetime risk of developing ovarian cancer. They also often develop cancer at a younger age than people without Lynch syndrome.

https://www.healthline.com/health/ovarian-cancer/lynch-syndrome-ovarian-cancer#ovarian-cancer-risk

PERCS study

PERCS is a research project funded by the Irish Cancer Society and run by a team based in the Trinity St James’s Cancer Institute.

Through PERCS, we will run and evaluate a new exercise rehabilitation triage and referral system for people who have completed cancer treatment in St James’s Hospital.

The aim of the rehabilitation and referral system is to help people who have had cancer to become more active and improve their overall health.

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