If Lynch syndrome runs in your family you really need to know.
Category: Colon
If I have Lynch syndrome, will I get cancer?
Not everyone with Lynch syndrome will develop cancer, but you have an increased risk compared to the general population. People with Lynch syndrome have an increased risk of developing some types of cancer, such as:
• bowel (colorectal)
• endometrial or uterine
• ovarian cancer.
Lynch syndrome causes 1 in every 35 cases of bowel cancer, 1 in every 50 cases of endometrial cancer.
Your risk of developing cancer depends on which gene is affected, your age and being male or female.
Check out http://www.plsd.eu
You’re Young, But It Might Be Cancer
At Digestive Cancers Europe(DiCE), they firmly believe that supporting early detection is essential for better outcomes and improving the quality of life for every patient.
By reading “You’re Young, But It Might Be Cancer,” you will gain valuable insights and perspectives from these brave survivors and contribute to DiCE’s efforts in raising awareness and empowering patients and their families.
https://digestivecancers.eu/youre-young-but-it-might-be-cancer/
Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data
Previous studies have shown that colorectal cancer incidence is increasing among younger adults (aged <50 years) in multiple high-income western countries in contrast with stabilising or decreasing trends in incidence in older adults (aged ≥50 years).
The increase in early-onset colorectal cancer, previously seen predominately in high-income western countries, has now been documented in various economies and regions worldwide, marking it as a global phenomenon.
The global reach of this alarming trend calls for innovative tools to prevent and control cancers linked to nutritional attributes, physical inactivity, and excess bodyweight, which might be more challenging to address than the tobacco epidemic.
Educational efforts to increase awareness of the increase in the incidence of early-onset colorectal cancer and its unique symptoms, especially among primary care providers, would have far reaching effects in reducing delayed diagnoses and mortality.
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(24)00600-4/fulltext
Bowel cancer rising among under-50s worldwide, research finds
Experts are still in the early stages of understanding the reasons behind the rise. The authors of the study, published in the Lancet Oncology, said consumption of junk food, high levels of physical inactivity and the obesity epidemic were likely to be among the factors.
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045%2824%2900600-4/fulltext
“Ongoing efforts are essential to identify the additional factors behind these trends and to develop effective prevention strategies tailored to younger generations and local resources worldwide.”
The overall number of cases in young adults was still low, with only about one in 20 bowel cancers in the UK diagnosed in people aged under 50.
Sung said it was critical that more people know the symptoms. “Raising awareness of the trend and the distinct symptoms of early-onset colorectal cancer (eg rectal bleeding, abdominal pain, altered bowel habits, and unexplained weight loss) among young people and primary care providers can help reduce delays in diagnosis and decrease mortality,”
‘Some good friends disappeared from my life’
What I really didn’t expect was some good friends of many years who I had spent a lot of time with simply disappeared out of my life. Some people said, “they obviously weren’t real friends” and initially I agreed, but I now try and be a bit more charitable. I think they probably couldn’t deal with the thought of someone they knew so well having a life-threatening disease or didn’t know what to say.
Tony, 63 was diagnosed with stage 3 colon cancer following a colonoscopy in late 2021, and had surgery and six months of chemotherapy.
He is aiming for a 50-mile run/walk competition in the Lake District in July 2024.
Uptake of Aspirin Chemoprevention in Patients With Lynch Syndrome
Two hundred and ninety-six participants completed the survey.
Uptake of regular ASA or NSAIDs was modest at 34.8% and was even lower (25.7%) when focusing on individuals taking ASA or NSAIDs solely for chemoprevention of LS. More than half (55%) were taking <100 mg ASA daily.
Conclusion: Patient perceptions of the pros and cons of ASA, more so than demographic and disease-related factors, were associated with chemoprevention uptake.
Bowels, Basics & Breakthroughs
Multigene Panel Testing Yields High Rates of Clinically Actionable Variants Among Patients With Colorectal Cancer
Purpose:
Whether germline multigene panel testing (MGPT) should be performed in all individuals with colorectal cancer (CRC) remains uncertain. Therefore, we aimed to determine the yield and potential clinical impact of MGPT across a large, diverse CRC cohort.
Conclusion
To our knowledge, this is the largest study(34,244) to date examining MGPT in CRC, demonstrating high rates of clinically actionable variants detected across all age groups, panel sizes, and racial/ethnic groups. This work supports consideration of broadening germline genetic testing criteria for individuals with CRC.
Why biomarkers matter
Your biomarker profile can help you and your doctor personalise your treatment.
Biomarkers for colorectal cancer are used for diagnosis, progression, prognosis, and for treatment planning.
MSI-H and MSS biomarkers indicate the stability of the DNA in a tumour.
Colorectal cancer tumours are often referred to as having an “MSI status,” meaning they are described as either MSI (microsatellite instable) or MSS (microsatellite stable). They cannot be both.
What does an abnormal MSI-H level mean?
Approximately 15% of colorectal tumours are MSI-H and dMMR.
In most of these cases, the mutation was caused by a non-hereditary(somatic) gene abnormality in one of the MMR genes (MLH1, MSH2, MSH6, or PMS2) in a cancer cell.
In 3-5% of colorectal patients, dMMR and MSI-H are caused by Lynch syndrome. In these patients, a hereditary mutation (germline mutation) in one of the four main MMR genes is passed from one generation to another. Individuals with Lynch syndrome are at higher risk of developing colorectal, endometrial (uterine), gastric, ovarian, and other cancers.
Lynch Syndrome Ireland 