If you’re a clinician or researcher in this space, the question isn’t:
“How do we give people more information?”
A better question is:
“How can we help equip & support patients to live with an uncertainty?”
Category: Uncategorized
VUS-
Variant of Uncertain Significance is a genetic test result indicating a change in your DNA, but scientists currently lack enough data to know if it is harmless or causes disease.
Determining whether a genomic variant is truly disease-causing is a rigorous scientific process.
“It requires robust evidence, internationally agreed standards, and often detailed discussion within multidisciplinary teams of clinicians, laboratory scientists, bioinformaticians, and genetic counsellors. Variants are not simply “found” and reported; they are carefully evaluated, challenged, and reviewed before any meaningful conclusions can be drawn.”
First trial of vaccine to prevent Lynch syndrome-associated cancers approved to start in Oxford
This MHRA authorisation marks an important milestone as we explore approaches to shift cancer care from treating disease to preventing it.
Phase 1 of the INTERCEPT-Lynch trial, which is funded by Moderna, sponsored by the University of Oxford and run by the University’s Oncology Clinical Trials Office with support from Oxford Cancer, has received authorisation from the Medicines and Healthcare products Regulatory Agency and is expected to begin recruiting participants this summer.
It will test ‘mRNA-4194’, an investigational mRNA-based vaccine developed by Moderna, which is designed to help prevent cancer in people with Lynch syndrome.
“People with Lynch syndrome live with a very high risk of developing cancer, often at a younger age than the general population. The INTERCEPT-Lynch trial represents a meaningful step in our efforts to prevent Lynch syndrome-associated cancers before they develop”
Awareness
#NationalCancerSurvivorsDay
“Research Creates Hope 🫶
Hope Creates Survivors 🙏🏻
ThankYou to every researcher, scientist, clinician, trial participant, and supporter involved in cancer research🔬without the dedication, innovation, and breakthroughs achieved over the years, would so many of us be here today?
Research saves lives, every discovery brings hope 🧪every trial opens new possibilities 🧫and every advancement gives more people the chance to become survivors👩🏽🔬
Today, we celebrate not only survivors but also those working tirelessly behind the scenes to make survival possible.”
Inherited Risk…..
Cancer treatments are better and continuing to improve
Chemo round 184…..
Lynch Syndrome: Why Upper Endoscopies and Colonoscopy Prep Save My Life
Key Takeaways
- Genotype-informed surveillance should pair colonoscopy with upper endoscopy when MLH1/MSH2 mutations or family history elevate gastric cancer risk.
- Finding benign polyps during routine scopes validates intensified screening in Lynch syndrome, shifting detection upstream before malignant transformation and reducing preventable mortality.
- Prep tolerability improves with pre-prep dietary lightening, chilled split-dose solutions, straw use, permitted clear-liquid chasers, aggressive hydration, and broth to support IV access.
- Risk management extends beyond endoscopy to anxiety coping, certified genetic counseling, early-age initiation of colonoscopy (often 20s or 10 years pre-index case), and individualized aspirin chemoprevention discussions.
St. Vincent’s University Hospital launch patient-centred Endoscopy Video Series.
Topics covered in the Endoscopy Video Series include:
- A Typical Patient Experience
- A Typical Colonoscopy Experience
- A Typical Gastroscopy Experience
- Colonoscopy Preparation – Diet
- Colonoscopy Bowel Preparation – Morning Appointment
- Colonoscopy Bowel Preparation – Afternoon Appointment
- Conscious Sedation
- After your Endoscopy.
Prevention Strategies for Hereditary Gynaecological Cancer in Lynch Syndrome
At this time, there are promising emerging technologies including bio-marker-based detection using DNA methylation analysis of cervicovaginal samples, liquid biopsies and microbiome profiling that may result in less invasive and more accurate methods for early cancer detection.
Lynch Syndrome Ireland 